This study evaluates the efficacy of Jatropha curcas oil and Eucalyptus globulos oil in the treatment of mange disease in goats for 42 days. Twelve West Africa dwarf goats all already infected with mange weighing between 4.5 kg and 7 kg with an average weight of 5.75 kg were randomly allocated into four treatments with 3 animals per treatment in a completely randomized design. The animals were subjected to zero treatment (A), Ivermectin Treatment (B), pure Jatropha oil Treatment (C) and pure Eucalyptus oil Treatment (D). Results show that there was significant difference (P<0.05) in average feed intake and average daily body weight gain among the Treatments. The average daily feed intake was 108.81 g/day (A), 140.24 g/day (B), 129.37 g/day (C) and 159.68 g/day (D). The haematological parameters of the blood were also examined and their mean were compared using student t-test. It was observed that the blood parameters examined fell within the range reported for goat. Additionally, the results showed significant differences (P<0.05) in Neutrophil and Lymphocytes among the Treatments. It could be concluded that the efficacy of Eucalyptus globulos oil in the treatment of mange in goat is more than that of Jatropha curcas oil.