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Status decision of controlled and non-controlled substance(S)

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Health Canada

Santé Canada



Substance: 11Tropine benzoate

Based on the current information available to the Office of Controlled Substances, it appears that the above substance is:
Controlled ✔

Not Controlled ☐

under the schedules of the Controlled Drugs and Substances Act (CDSA) for the following reason(s):

  • 1The substance is an alkaloid of coca and is captured in item 2 of Schedule I to the CDSA.

Prepared by: _______________________________________ Date: _______________

Vincent Marleau

Verified by: _______________________________________ Date: ________________

Mark Kozlowski

Approved by: _______________________________________ Date: ________________


This status was requested by: Anne-Marie Fortin, DAS

Drug Status Report

Drug: 1 Tropine benzoate
1Drug Name Status: 1 Tropine benzoate is the common name.
Chemical Name: 8-Azabicyclo(3.2.1)octan-3-ol, 8-methyl-, benzoate (ester),

Other Names: (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl benzoate

Chemical structure:

Molecular Formula: 1C15H19NO2 1CAS-RN: 19145-60-9


Pharmacological class / Application: Alkaloid of Coca (erythoxylon)


International status:

US: 1 Tropine benzoate is not listed specifically in the Schedules to the US Controlled Substances Act and is not mentioned anywhere on the DEA website.

United Nations: The substance is not listed on the Yellow List - List of Narcotic Drugs under International Control, the Green List - List of Psychotropic Substances under International Control, nor the Red List - List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances under International Control.

Canadian Status: 11 Tropine benzoate is not specifically listed in the Schedules to the CDSA. The substance is an alkaloid of Coca (ethroxylon)1, which is listed as item 2 in Schedule I to the CDSA under the heading “Coca (Erythroxylon), its preparations, derivatives, alkaloids and salts, including:”. As an alkaloid of coca, tropine benzoate must be included under item 2 of Schedule I to the CDSA.

Recommendation: 1 Tropine benzoate is included under item 2 of Schedule I to the CDSA and is a controlled substance.
Date: November 8th, 2012.

1 Novak, M. et al. (1984) Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense. Journal of Ethnopharmacology. 10(3): pp.261-274.

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