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INTERNATIONAL SYMPOSIUM

Control of gene expression and cancer



dedicated to the 20th anniversary of

the Institute of Gene Biology,

Russian Academy of Sciences


PROGRAMME

June 21-25, 2010

Moscow, Russia
International Symposium

Control of gene expression and cancer”



web-site
www.molecularoncology.ru



Venues for the Symposium events

Institute of Gene Biology, Russian Academy of Sciences

34/5 Vavilov street, Moscow

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

32 Vavilov street, Moscow
International Symposium “Control of Gene Expression and Cancer” is organized by



Institute of Gene Biology, Russian Academy of Sciences

www.genebiology.ru

with the support from






Russian Foundation for Basic Research

www.rfbr.com

Presidium of the Russian Academy of Sciences,

program “General Academy Events”

www.ras.ru

and in partnership with






Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

www.eimb.ru





Bio-Rad Laboratories Ltd.



www.bio-rad.com

Helicon Сompany Ltd.

www.helicon.ru




Acrus

www.acrus.ru

InterLabService Ltd., Co.

www.interlabservice.ru



Biogen-Analytika Ltd.

www.bga.su

Sunday, June 20th, 2010
Arrival of participants
Monday, June 21th, 2010
9:30-10.15 Registration (Engelhardt Institute of Molecular Biology, 3rd floor)
10:15-10:30 Opening of the symposium (Engelhardt Institute of Molecular Biology, the main conference hall)

Georgii Georgiev, Nikolai Gnuchev

Part I: Control of gene expression
Session I: Insulator paradigms, boundaries and long-distance interactions

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Klaus Scherrer, Konstantin Severinov

10:30-11:00 Fab-7 boundary and the Elba factor: “Able was I ere I saw Elba”



Paul Schedl
11:00-11:30 Epigenetic regulation controlled by the insulator factor CTCF

Rainer Renkawitz
11:30-12:00 Coffee break
Chairpersons: Peter Becker, Vladimir Gvozdev

12:00-12:30 Chromatin Insulators in Drosophila melanogaster



Pavel Georgiev
12:30-13:00 Nuclear distribution of insulator proteins in Drosophila melanogaster

Anton Golovnin
13:00-13:30 In situ dissection of a chromatin regulatory domain of the bithorax complex in Drosophila

Francois Karch
13:30-15:00 Lunch break

Session II: Chromatin and chromatin domains - 1

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Laszlo Tora, Pavel Georgiev

15:00-15:30 Fundamental principles of interphase chromosomes organization in eukaryotes



Igor Zhimulev
15:30-16:00 Regulatory architecture in the Drosophila genome

Rob White
16:00-16:30 Regulation of gene expression in functional chromatin domains

Sergey Razin
16:30-17:00 Coffee break
Chairpersons: Elissa Lei, Anton Golovnin

17:00-17:30 Chromatin dynamics in development and disease



Peter Verrijzer
17:30-18:00 Multiple functions of the Origin Recognition complex

Igor Chesnokov
18:00-18:30 Mutations as factors affecting genetic variation in clonally reproduced (parthenogenetic) lizards

Alexey Ryskov
18:30 Free time and dinner

Tuesday, June 22th, 2010
Session III: Genome and factors of transcription control - 1

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Francois Karch, Alexey Ryskov

10:00-10:30 Signaling to and through chromatin modifying complexes



Jerry Workman
10:30-11:00 Harnessing the acetyltransferase MOF for genome-wide fine - tuning of transcription

Peter Becker
11:00-11:30 The role of metazoan ATAC and SAGA acetyl-transferase complexes in the control of gene expression and mitotic progression

Laszlo Tora
11:30-12:00 Coffee break
Chairpersons: Jerry Workman, Igor Zhimulev

12:00-12:30 ENY2 protein in metazoan links transcription and mRNA export



Sofia Georgieva
12:30-13:00 Sus1 is a unique factor coupling different steps of gene expression

Susana Rodriguez-Navarro
13:00-13:30 Mechanism of transcription activation by factor SAYP

Yulii Shidlovsky, Yurii Ilyin
13:30-15:00 Lunch break

Session IV. RNA and transcription control

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Peter Verrijzer, Sofia Georgieva

15:00-15:30 piRNA-mediated gene silencing mechanisms in Drosophila germlines



Mikiko Siomi
15:30-16:00 Segregation of stem cell renewal and silencing functions of PIWI protein

Mikhail Klenov, Vladimir Gvozdev
16:00-16:30 Endogenous siRNAs in Drosophila: biogenesis, function, and its implication in human disease

Huruhiko Siomi
16:30-17:00 RNA dependent chromatin organization

Elissa Lei
17:00-17:30 Coffee break

Session V. Procaryotic transcription and general theory

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Rob White, Sergey Razin

17:30-18:00 Discovery and analysis of a novel class of DNA-dependent RNA polymerase encoded by a virus infecting a thermophilic bacterium



Konstantin Severinov
18:00-18:30 Gene and genon concept and the transcription factor cycle (TFC) Hypothesis

Klaus Scherrer
18.30-19.30 POSTER SESSION (Engelhardt Institute of Molecular Biology, 3rd floor)
19:30 Free time and dinner

Part II: Cancer molecular genetics
Wednesday, June 23th, 2010
Session VI: Molecular biology of tumor cell - 1

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Jonathan Chernoff, Igor Korobko

10:00-10:30 Causes and Consequences of microRNA dysregulation in Cancer



Carlo Croce
10:30-11:00 Genes oppositely regulated in cancer and development as candidate genes causing cancer

Eugene Sverdlov
11:00-11:30 Control of cancer related genes with chemically modified siRNAs

Valentin Vlassov
11:30-11:50 Coffee break
11:50-12:20 Potential roles of sestrins in aging and diseases

Peter Chumakov
12:20-12:50 Quiescent cells in solid tumors

Stefan Krauss
12:50-13:20 Wnt signaling and cell polarity during vertebrate development

Sergei Sokol
13:20-15:30 Lunch break

Session VII: New targets and models for therapy development

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Stefan Krauss, Eugine Sverdlov

15:30-16:00 Antibody-mediated chemical transformation



Alexander Gabibov

16:00-16:30 Inhibiting p21-activated kinases: thinking outside the (catalytic) box



Jonathan Chernoff

16:30-17:00 Deletion of HEF1 protein as the new therapeutic approach for treatment metastatic breast cancer



Elena Pugacheva

17:00-17:30 Coffee break
17:30-18:00 The role of S100A4 in tumor/stroma interplay

Eugene Lukanidin

18:00-18:30 Therapeutic antitumor immune response: natural surveillance or artificial self-reactivity



Sergey Larin
18:30-19:00 Toll-like receptors, chronic inflammation, and cancer

Felix Yarovinsky

19.00-20.00 POSTER SESSION (Engelhardt Institute of Molecular Biology, 3rd floor)


20:00 Free time and dinner

Thursday , June 24th, 2010
Session VIII: Tumor immunology

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Alexander Sobolev, Michael Zalutsky

10:00-10:30 On the mechanism of target cell destruction by cytolytic effectors



Yuri Sykulev
10:30-11:00 New approach to understanding of the immune defense mechanisms: Three proteins metastasin (S100A4), Hsp70, Tag7 (PGRP-S) in host vs. cancer defense

Denis Yashin, Lidia Sashchenko
11:00-11:30 Tumor necrosis factor, lymphotoxin and cancer

Sergey Nedospasov
11:30-11:50 Coffee break

Session IX: Novel approaches in cancer treatment - 1

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Andrey Gudkov, Valentin Vlassov

11:50-12:20 Perspectives of Pdcd4 gene therapy for lung cancer



Igor Korobko
12:20-12:50 Microtubules and mitochondria connection for cancer treatment

Diane Braguer
12:50-13:20 Molecular mechanisms underlining the loss of GJ-mediated intercellular communications in cancer

Irina Majoul

13:20-15:30 Lunch break

Session X: Smart molecules for treatment and diagnostics

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Sergei Sokol, Sergey Larin

15:30-16:00 Molecular colonies as a research and diagnostic tool



Alexander Chetverin
16:00-16:30 Modular nanotransporters delivering drugs into the nuclei of target cells

Alexander Sobolev
16:30-17:00 Genetically encoded self-nanoassembler

Sergey Deyev
17:00-17:30 Coffee break
17:30-18:00 Targeting Alpha Particles to Cancer: A cellular Approach to Radiation Therapy

Michael Zalutsky

18:00-18:30 Redefining druggability: targeting transcriptional control by small molecules



Andrey Gudkov

18:30-19:00 Recombinant human lactoferrin in healthcare-associated infections control



Elena Sadchikova
19:20 BANQUET A LA FOURCHETTE (Institute of Gene Biology, 1st floor)

Friday, June 25th, 2010
Sessions XI-XIII and Sessions XIV-XV will be held in parallel in the Engelhardt main conference hall and the mail conference hall of the Engelhardt Institute of Molecular Biology
Part II: Cancer molecular genetics (continued)
Session XI: Molecular biology of tumor cell -2

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Sergey Tillib, Pavel Sergeev

10:00-10:25 Lysine Methyltransferase Set7/9 controls cell cycle via cyclin E-dependent mechanism



Nickolai Barlev
10:25-10:50 Effect of Wnt11 ligand alterative splicing on Wnt signaling regulation

Alexey Kibardin
10:50-11:15 Rho GTPase Chp/RhoV as a regulator of cytoskeleton: implications for cancer cell biology

Mikhail Shepelev
11:15-11:40 New RT PCR instrument (CFX96) and HRM (High Resolution Melting) technology applications for molecular diagnostics

Maria Nemykh
11:40-12:05 Coffee break

Session XII: Novel approaches in cancer treatment - 2

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Elena Sadchikova, Nikolai Barlev

12:05-12:30 Camelus bactrianus is a convenient animal for generation of wide spectrum of specific single-domain mini-antibodies (nanobodies®)



Sergey Tillib
12:30-12:55 DNA-template directed synthesis to treat cancer diseases

Pavel Sergeev
12:55-13:20 Polyplex nanoparticles, their physico-chemical properties, and in vitro/in vivo transfection ability

Andrey Rosenkranz

13:20-15:00 Lunch break

Session XIII: Molecular genetics of cancer

(Engelhardt Institute of Molecular Biology, the main conference hall)



Chairpersons: Nikolai Gnuchev, Alexey Kibardin

15:00-15:25 SEQUENOM MassArray for gene expression and cancer studies



Maxim Patrin
15:25-15:50 Molecular genetic alterations in prostate cancer and its microenvironment

Tatiana Kekeeva
15:50-16:15 Genetic and epigenetic aberrations: diagnostic and therapeutic implications in gliomas and some other cells in culture

Tatyana Shtam
16:15-16:40 Cathepsin D mRNA level is reduced in lung cancer

Andrey Shubin
16:40-16:55 EliSpot technology: modern equipment and test-systems for immune reaction examination

Dmitry Kuevda
16:55-17:05 Concluding remarks

Nikolai Gnuchev
Part I: Control of gene expression (continued)
Session XIV: Chromatin and chromatin domains - 2

(Engelhardt Institute of Molecular Biology, the Engelhardt conference hall)



Chairpersons: Igor Chesnokov, Petr Rubtsov

10:00-10:25 CHD1 is a major factor in replication-independent nucleosome assembly



Alexander Konev
10:25-10:50 Enhancer chooses promoter: cis-preference or trans-activation

Mikhail Savitsky
10:50-11:15 Selective interactions of boundaries with upstream region of Abd-B promoter in Drosophila bithorax complex and role of dCTCF in this process

Olga Kyrchanova
11:15-11:40 Mapping of the nuclear matrix-bound chromatin hubs by a new M3C experimental procedure

Alexey Gavrilov
11:40-12:05 Coffee break

Session XV: Genome and factors of transcription control - 2

(Engelhardt Institute of Molecular Biology, the Engelhardt conference hall)



Chairpersons: Alexander Konev, Mikhail Savitsky

12:05-12:30 ENY2 protein links Su(Hw)-dependent insulators and SAGA/TFTC complex



Aleksey Krasnov
12:30-12:55 SAYP participates in transcriptional regulation of ecdysone-dependent genes on different levels of PIC formation

Nadezhda Vorobyeva
12:55-13:20 Domain organization (architectural structure) of Drosophila CTCF protein

Oksana Maksimenko

13:20-15:00 Lunch break
Chairpersons: Georgii Georgiev, Aleksey Krasnov

15:00-15:25 Novel potential partners and novel functions of atypical nuclear receptor DAX1, an important regulator of adrenal and gonadal development



Petr Rubtsov
15:25-15:50 The function of TBP-related protein TRF2 in transcription regulation

Daria Kopytova
15:50-16:15 Regulation of human RUNX1 gene expression

Elena Markova
16:15-16:40 The short-lived mammalian homologue of SAYP – PHF10 has ubiquitous expression

Nataliya Soshnikova
16:40-16:55 Carrying out SNP and epigenetic researches with the use of pyrosequencing technology

Vyacheslav Kolotvin
16:55-17:05 Concluding remarks

Georgii Georgiev

Saturday, June 26th, 2010
Departure of participants



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