NAME: Kenneth R. Chien;
BORN: November 24, 1951; Woodbury, New Jersey, USA
WORK ADDRESS: Department of Cell and Molecular Biology
SE-171 77 Stockholm SWEDEN
Ph: +46 8 524 86365
Professor, Karolinska Institutet, Departments of Cell and Molecular Biology and of Medicine (tenured from 2013).
Director, Department of Cardiology, Karolinska University Hospital
Professor (Visiting), Harvard University, Department of Stem Cell and Regenerative Biology.
ACADEMIC EDUCATION & SCIENTIFIC DEGREES:
1973 BA Biology, Harvard College, USA.
1980 MD Medicine, Temple University School of Medicine, USA.
1983 PhD Medicine, Temple University School of Medicine, USA.
(PhD advisor John Farber, MD).
Licensure and Certification
1988 Medical Board of California #G63639
PREVIOUS ACADEMIC POSITIONS:
1984-1988: Assistant Professor of Medicine, Cardiology Division, University of Texas Southwestern, Medical Center, Dallas, TX USA
1988-1992: Associate Professor of Medicine, Department of Medicine and Member Center for Molecular Genetics, University of California, San Diego, CA, USA
1992-2005: Professor of Medicine, Department of Medicine and Member Center for Molecular Genetics, University of California, San Diego, CA, USA
2000-2005: Director, Institute of Molecular Medicine, University of California, San Diego, CA, USA
2000-2008: Professor, Salk Institute (Adjunct), San Diego, CA, USA
2005-2012: Professor of Medicine &Cell Biology, Harvard Medical School, Boston, MA, USA
2005-2012: Charles Addison & Elizabeth Ann Sanders Endowed Chair in Medicine, Harvard Medical School, Boston, MA, USA
2005-2012: Professor, Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA
1981-1982: Residency Medicine Parkland Memorial Hospital, Dallas, USA
1982-1984: Clinical Cardiology, University of Texas Southwestern Research Medical center, Dallas, TX, USA. Fellowship
- 276 publications, including 243 original articles (h-index 88).
- Have invited presentations at numerous international scientific conferences. (Nobel Conferences, Oxford, Stanford, Keystone etc)
HONORS AND AWARDS:
The Pasarow Foundation Medical Research Award / Research
(Co-recipients: Stanley Prusiner (Neuroscience) and Alfred G. Knudson (Cancer)), 1996
American Heart Association-United Way Combined Health Agency Health Hero Award / Research, 1996
The Temple University Alumni Achievement Award, Philadelphia, PA / Research, 2000
American Heart Association Endowed Chair in Cardiovascular Research (California Affiliate), 2000-2005
Temple University Alumni Assoc. School of Medicine Certificate of Honor, Philadelphia, PA 2003
Honorary Degree of Doctor of Science, The University of Edinburgh, Edinburgh Scotland, 2008
Sander’s Chair of Medical Science, Harvard University, Cambridge, MA
COMISSIONS OF TRUST:
Member, Advisory Board (Biotechnology lnvestment Fund). Pictet and Cie Banquiers, Geneva, Switzerland [1997 -]
Member, The Pasarow Medical Research Foundation Board and Award Committee [1998 – 2005]
Member, Pre-Doctoral Fellowship Review Panel, (National Academy of Sciences/Howard Hughes Medical Institute [1999 – 2000]
Advisor, lntegrative Biology Program. Medical Research Council, UK [1999 – 2001]
Member, International Advisory Panel, Wellcome Trust, UK [2000 – 2007]
Advisor, Doris Duke Charitable Foundation, Co-Chair (2000-2002), Innovative Clinical Research Awards; Chair (2002-2005), Clinical lnterfaces Program [2000 - 2008]
Consultant, Scientific Advisory Board, Donald W Reynolds Foundation [2001 - 2002]
Advisor, Helmholtz Foundation, Germany 
Member, International Scientific Advisory Board, The Baker Institute, Melbourne, Australia [2002 -2005]
Member, Hong Kong Science and Technology Board, Hong Kong, China [2005 – 2007]
Member, Scientific Jury, lnterbrew-Baillet La Tour Prize, Brussels, Belgium 
Member, Int' l Scientific Adv Board, Wellcome Trust Centre for Human Genetics. London, UK [2005 – 2006]
Member, Scientific Advisory Board, lnst of Molecular Biotechnology Assoc Vienna, Austria [2007-2012]
Member, British Heart Foundation Centre of Research Excellence Ext Adv Board [2009 – 2011]
Corresponding Member/IMP/IMBNExecutive Committee Abroad/Section for Mathematics and the Natural Sciences/Austrian Academy of Sciences/Vienna, Austria 
Member, NIH/NHLBI Board of Sci Counselors/Division of Intramural Research [2009 –2011]
Advisor and Speaker, Nobel Forum of Regenerative Medicine 2010. Stockholm, [2010 –]
Advisor, Centre Nacional de lnvestigaciones Cardiovasculares-CNIC/Sci Adv Board,
Madrid, SPAIN [2011 –]
Visiting professorship, Hong Kong University, [2010 –]
MAJOR ADMINISTRATIVE LEADERSHIP POSITIONS:
Director of the Institute of Molecular Medicine and NHLBI Joint UCSD-Salk Training Program in Molecular Medicine, UCSD (2000 – 2005)
Associate Chief of Cardiology for Research and Director of the Cardiovascular Research Center, Massachusetts General Hospital (2005-2012)
Director, Cardiovascular Disease Program, Harvard Stem Cell Institute (2006-2009)
Faculty Member, Center for Stem Cell and Regenerative Biology, Harvard University (2009-)
Member, American Society for Clinical lnvestigation 1990 -
Foreign Member Elect, Norwegian Academy of Sciences 2004 -
Member, American Heart Association 2005 -
Member, American Society of Gene Therapy 2005 -
Foreign Member Elect, Austrian Academy of Science 2009 -
TEN SELECTED PUBLICATIONS:
Domian IJ, Chiravuri M, et al, Chien KR. (2009) Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science326, 426-9.
Bu L, Jiang X, Martin-Puig S, et al, Chien KR. Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009 Jul 2;460(7251):113-7.
Qyang Y, Martin-Puig S, et al, Chien KR. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2007 Aug 16;1(2):165-79.
Moretti A, Caron L, et al, Chien KR. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15;127(6):1151-65.
Laugwitz KL, Moretti A, et al, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10;433(7026):647-53. Erratum in: Nature. 2007 446, 934.
Pashmforoush M, Lu JT, et al, Chien KR. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell 2004 Apr 30;117(3):373-86.
Knöll R, Hoshijima M, et al, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002 Dec 27;111(7):943-55.
Hoshijima M, Ikeda Y, et al, Chien KR. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med. 2002 Aug;8(8):864-71.
Minamisawa S, Hoshijima M, et al, Chien KR. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 1999 Oct 29;99(3):313-22.
Hirota H, Chen J, et al, Chien KR. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell. 1999 Apr 16;97(2):189-98.